WELCOME TO THE GIANETTI GROUP
Photocatalysis - Redox Flow battery - Organometallic Chemistry - Frustrated Lewis Pairs
PHOTOREDOX Α-ARYLATION OF CYCLIC KETONES"
The direct α-arylation of carbonyl compounds using aryl halides represents a powerful method to synthesize critical building blocks for diverse useful compounds. Numerous synthetic methods exist to forge C(sp2)–C(sp3) bonds although mild and metal-free direct α-arylation of ketones remains a challenging transformation. Here we report a green-light-mediated α-arylation of ketones from readily available aryl halides via activation of a C(sp2)–X bond (X = I, Br, Cl) and an α-carbonyl C(sp3)–H bond in a single photocatalytic cycle. This approach is characterized by its mild reaction conditions, operational simplicity and wide functional group tolerance. Importantly, the impressive outcome of the multigram photocatalytic reaction underpins the strength of this method as a potentially practical and attractive approach for scale-up industrial purposes. The utility and scope of this reaction were further demonstrated by formal syntheses of several feedstock chemicals that are commercially expensive but critical for synthesizing numerous pharmaceutical agents.
THE GROUP RECEIVED AN NSF CAREER AWARD
The Gianetti group received a grant of $558k for 5 years from the NSF Chemical Catalysis, for our work on “Red-light mediated photoredox catalysis by helical carbenium ions".
THE GROUP RECEIVED AN NSF GRANT
The Gianetti group received a grant of $475k for 3 years from the NSF Chemical Synthesis, for our work on “ Development of Stable Carbocations for Lewis Acid-Assisted Transformations".
THE GROUP RECEIVED AN NSF I-CORPS GRANT
I-Corps enables the transformation of invention to impact. The curriculum integrates scientific inquiry and industrial discovery in an inclusive, data-driven culture driven by rigor, relevance, and evidence. Through I-Corps training, researchers can reduce the time to translate a promising idea from the laboratory to the marketplace.
T. GIANETTI RECEIVED THE 2021 COTTRELL SCHOLARS AWARD
Recipients are chosen through a rigorous peer-review process of applications from top research universities, degree-granting research institutes, and primarily undergraduate institutions in the United States and Canada. Their award proposals incorporate both science education and research.